Sarcopenia, which is defined as the loss of muscle mass related to old age, contributes to the loss of functional mobility and independence (4-7). Since physical incapacity often occurs in the elderly, it is estimated that from 20 to 30% of individuals over 70 years of age experience incapacity in the performance of tasks that require mobility and locomotion, the activities of daily living (ADLs) and instrumental activities of daily living (IADLs) (2,3). Between 19, it is expected that the world's elderly population will have grown by 223% (1). In developing countries, socioeconomic development often does not keep pace with the aging of the population (1). It is also, however, accompanied by tremendous challenges. Key words: Muscle strength Interleukin-6 Elderly women Sarcopenia Aging IL-6 IntroductionĮxtended lifespan is one of the greatest triumphs of humanity. These results suggest that IL-6 is associated with reduced muscle strength. No significant correlation was observed between IL-6 levels and the functional tests (time to rise from a chair = 14.65 ± 2.82 s and gait velocity = 0.95 ± 0.14 m/s). Post hoc analysis was performed using the Dunn test. After the Shapiro-Wilk normality test was applied, correlations were investigated using Spearman and Kruskal-Wallis tests.
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Muscle strength was assessed with the isokinetic dynamometer Biodex System 3 Pro ®. Serum levels of IL-6 were measured in duplicate and were performed within one single assay (mouse monoclonal antibody against IL-6 High-Sensitivity, Quantikine ®, R & D Systems, USA intra-assay coefficient of variance = 6.9-7.4% interassay coefficient of variance = 9.6-6.5% sensitivity = 0.016-0.110 pg/mL mean = 0.039 pg/mL). IL-6 levels, isokinetic muscle strength of knee flexion/extension, and functional tests to determine time required to rise from a chair and gait velocity were measured in 57 participants (71.21 ± 7.38 years). Psychological and social stress due to unsuccessfully aging can represent a risk for immune system disfunctions. Elderly people who present controlled chronic diseases with no negative impact on physical, psychosocial and mental functionality are considered to be community-dwelling. The association of plasma interleukin-6 (IL-6) levels, muscle strength and functional capacity was investigated in a cross-sectional study of community-dwelling elderly women from Belo Horizonte, Brazil. Pereiraĭepartamento de Fisioterapia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil Muscle strength but not functional capacity is associated with plasma interleukin-6 levels of community-dwelling elderly womenĭ.M.G. Muscle strength Interleukin-6 Elderly women Sarcopenia Aging IL-6īraz J Med Biol Res, December 2008, Volume 41(12) 1148-1153 Muscle strength was assessed with the isokinetic dynamometer Biodex System 3 Pro®. Serum levels of IL-6 were measured in duplicate and were performed within one single assay (mouse monoclonal antibody against IL-6 High-Sensitivity, Quantikine®, R & D Systems, USA intra-assay coefficient of variance = 6.9-7.4% interassay coefficient of variance = 9.6-6.5% sensitivity = 0.016-0.110 pg/mL mean = 0.039 pg/mL).
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